Plant-derived Hemostatic Powder Exhibits Potential in the Managing Gastrointestinal Bleeding

hemostatic powder
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A research team from Severance Hospital has unveiled that a hemostatic powder derived from plant extracts markedly enhances the initial hemostasis success rate among patients suffering from gastrointestinal bleeding caused by peptic ulcers.

Peptic ulcers, arising from the erosion of the stomach or small intestine lining due to digestive acid rather than food digestion, can lead to severe bleeding. Failure to promptly and effectively manage this bleeding can result in complications like organ wall perforation or even death, particularly in patients aged over 65, where mortality rates can reach 10 percent.

Conventional treatments for such bleeding have encompassed vascular clip application, thermal coagulation, and electrocoagulation, all necessitating considerable time and expertise for successful execution.

Recently, there has been a growing utilization of the treatment method involving the application of powder onto the affected area. This trend is attributed to its ability to shorten treatment duration and ease of use, with minimal influence from the physician’s skill level. Additionally, the plant-derived ingredients are associated with almost negligible side effects. However, until now, there has been a lack of research confirming the treatment’s effectiveness.

To validate the efficacy of this treatment, a research team led by Professors Park Jun-chul and Jung Da-hyun from the Department of Internal Medicine conducted a study involving 216 patients who presented with bleeding from peptic ulcers at emergency rooms in four hospitals in Korea.

The study compared the effectiveness of the plant-extract-based hemostatic powder with traditional methods. This powder, derived from plant starches and containing absorbent polymers (AMPs) that expedite wound site regeneration and hemostasis, demonstrated an initial hemostasis success rate of 87.6 percent in the treated group (105 patients), slightly surpassing the 86.5 percent success rate observed in the group treated with traditional methods (111 patients).

Remarkably, when the ulcer had progressed to the extent of revealing underlying arterial vessels, the powder attained a 100 percent success rate in initial hemostasis, contrasting with the 86.4 percent achieved with conventional treatments.

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